SAN DIEGO--(BUSINESS WIRE)--Arcturus Therapeutics Holdings Inc. (the “Company”, “Arcturus”, Nasdaq: ARCT), a commercial messenger RNA medicines company focused on the development of infectious disease vaccines and opportunities within liver and respiratory rare diseases, today announced that the U.S. Food and Drug Administration (FDA) has issued a “Study Can Proceed” notification for the Company’s Investigational New Drug (IND) application, ARCT-2304, a self-amplifying mRNA (sa-mRNA) vaccine candidate for active immunization to prevent pandemic influenza disease caused by H5N1 virus. The clinical study is funded by Biomedical Advanced Research and Development Authority (BARDA) and designed to enroll approximately 200 healthy adults in the United States.

The Phase 1 clinical trial is designed to evaluate the safety, reactogenicity, and immunogenicity of ARCT-2304 as a potential vaccine to protect against the highly pathogenic H5N1 avian influenza.

"Arcturus is actively engaged with the U.S. government to prepare for the next pandemic, and clearance to proceed into the clinic with our STARR® self-amplifying mRNA technology is a key step in this important process,” said Joseph Payne, President & CEO of Arcturus Therapeutics. “The Phase 1 clinical trial is designed to evaluate the safety, reactogenicity, and immunogenicity of ARCT-2304 as a potential vaccine to protect against the highly pathogenic H5N1 avian influenza.”

About ARCT-2304

ARCT-2304 is a sa-mRNA vaccine candidate formulated within a lipid nanoparticle (LNP). The sa-mRNA vaccine candidate is designed to make many copies of mRNA within the host cell after intramuscular injection to achieve enhanced expression of haemagglutinin (HA) and neuraminidase (NA) antigens, thereby enabling lower doses than conventional mRNA vaccines. Utilizing a mRNA-based platform for pandemic influenza vaccine development offers further options for meeting domestic vaccine manufacturing surge capacity goals. The technology may make vaccines available much sooner than egg- and cell-based technologies. The lyophilized vaccine formulation is stable in refrigerators, thereby simplifying cold-chain storage and reducing distribution risks.

Stolen from Comrade Sisko

Who will leave a like for those who sacrificed everything to protect our freedoms from totalitarian regimes

I try reading about the Secret Treaties in Wikipedia, but it's not super conclusive.

I'm a longbow person because I value quantity over quality.

I swapped to Harry's a few years back as they're one of the few vegan brands. But this shit is frustrating. Those little rubber side pieces are load bearing and made thin enough that they're gonna break after a while.

I literally can't remember the leftist word for a product that's designed to break after some time.

No shame directed at the bearded comrades, but damn shaving helps get a tight seal with N95s.

I was at this school event where my laptop was plugged in near a lot of foot traffic. Admittedly I was too lazy to get a new battery and it's partly my fault. So my plug got kicked a bunch of times. My laptop restarted and updated, then restarted a bunch more fucking times because people kept kicking the cable. Now Windows is broken, and even using a repair USB won't fix it.

Like seriously, why does Windows, and sometimes Android, decide now's the time to do an update after a hard restart?!?!?

Feck.

I did a good faith search for the 90 000 number for Cuba, and I can only see US government sources and Cuba dissident groups. Cuba's own reports put this at half the number, which puts them well below Amerika.

From here.

I'm tired of you all holding back Palestine.

Stolen from here