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Her study found the glymphatic clearance was mediated by a hormone called norepinephrine and happened almost exclusively during the NREM sleep phase. But it only worked when sleep was natural. Anesthesia and sleeping pills shut this process down nearly completely.

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[-] intensely_human@lemm.ee 5 points 17 hours ago

If you want your brain to clean out waste at night, you need to be taking sweeping pills.

[-] sunzu2@thebrainbin.org 11 points 22 hours ago

Alcohol and weed does the same thing, just because you are out. Doesn't mean you are sleeping.

Good to see this common sense being confirmed

[-] flicker@lemmy.dbzer0.com 27 points 1 day ago

I have ADHD. Without drugs, I only sleep during the day, and sometimes, I'll skip a day and feel like crap about it no matter what I do.

I mean without drugs. I used to be an all-natural whackadoo.

Nowadays I do drugs about it and I'm allowed to be a real human. Guess my brain will clean itself when I die.

[-] pelespirit@sh.itjust.works 9 points 1 day ago

Be careful about assuming that your drugs are what they're talking about. Yours sound like they're balancing you out. They could be cleaning out your brain. Make sure to look at the study carefully.

[-] ChadMcTruth@lemmy.world -3 points 22 hours ago

you probably just need fresh nutrients

[-] Gullible@sh.itjust.works 59 points 1 day ago

This has been fairly well known for at least 15 years among medi-academia. But discovering the specific pathways involved leaves me (femininely) turgid

[-] nooneescapesthelaw@mander.xyz 7 points 19 hours ago

Obviously I understand what femininely turgid means but can you explain it just in case somebody else doesn't know?

[-] scarabic@lemmy.world 7 points 18 hours ago

ie: ladyboner, the old slip n slide, juices flowing, mine honeypot overfloweth

[-] nomy@lemmy.zip 3 points 17 hours ago

Like a lil cashew down there.

[-] RobotToaster@mander.xyz 42 points 1 day ago

The study was only on zolpidem. IMO it can probably be generalised to other Z drugs, and possibly benzos. Drugs that work by entirely different mechanisms like melatonin and orexin antagonists could be completely different.

[-] __nobodynowhere@lemm.ee 7 points 1 day ago
[-] rickyrigatoni@lemm.ee 28 points 1 day ago

The hat man cleans your brain for you.

[-] RobotToaster@mander.xyz 8 points 1 day ago

Unknown, but it's an anticholinergic, and those are associated with dementia.

[-] workerONE@lemmy.world 11 points 1 day ago
[-] TypicalHog@lemm.ee 3 points 22 hours ago

Suppresses dreams and dreams are apparently good and needed for a healthy brain.

[-] sunzu2@thebrainbin.org 2 points 22 hours ago

Se thing as any other substance

Weed too

[-] workerONE@lemmy.world 1 points 19 hours ago
[-] sunzu2@thebrainbin.org 2 points 19 hours ago

That shit don't last long enough?

[-] Agent641@lemmy.world 6 points 1 day ago
[-] rosa666parks@lemmy.dbzer0.com 2 points 1 day ago

Then gets you really sleepy

[-] sunzu2@thebrainbin.org 1 points 22 hours ago

Being knocked out is not sleep.

[-] anarchrist@lemmy.dbzer0.com 15 points 1 day ago

I wonder if ketamine has the same effect, he asked apropos of nothing...

[-] metaStatic@kbin.earth 12 points 1 day ago
[-] MossyFeathers@pawb.social 12 points 1 day ago

Actually maybe not? Iirc most "traditional" anesthesia basically knocks you down to the bare minimum of brain activity to remain alive and reliably regain consciousness (which is why being under anesthesia is usually a "blink and you miss it" ordeal, your brain isn't active enough to be aware that time has passed).

However, if I'm not mistaken, stuff like ketamine or nitrous don't do that, and sedate you in a manner more similar to natural sleep.

[-] some_guy@lemmy.sdf.org 6 points 1 day ago

Eff. I require sleeping pills. I guess I can look forward to a melted brain in old age.

[-] TacoButtPlug@sh.itjust.works 5 points 1 day ago

I wonder what melatonin does

[-] TypicalHog@lemm.ee 5 points 22 hours ago

It's a natural hormone brain produces that signals to the body that it's zzz time.

[-] TacoButtPlug@sh.itjust.works 2 points 17 hours ago

I love it for bedtime and it helps my autoimmune shit. Glad it's not brain bad.

[-] Agent641@lemmy.world 5 points 1 day ago

Forget melatonin, I want to know wtf cheese is doing to my brain when I sleep on it.

[-] SirQuackTheDuck@lemmy.world 7 points 19 hours ago

Probably just stick to the side of your head.

Have you tried eating the cheese instead?

[-] TacoButtPlug@sh.itjust.works 4 points 1 day ago

Charlie Kelly... who taught you about Lemmy?

[-] DaCrazyJamez@sh.itjust.works 2 points 1 day ago

Im pretty sure cat food and spray paint shut down m9re than just the NREM cycle in the brain...

[-] Hackworth@lemmy.world 4 points 1 day ago* (last edited 1 day ago)

You need healthy, natural sleep. Chew some valerian root and get more exercise.

[-] RvTV95XBeo@sh.itjust.works 7 points 1 day ago

That usually helps me sleep better too

Apparently the water supply in my town is dosed with sleeping pills.

[-] pelespirit@sh.itjust.works 9 points 1 day ago

Honestly, it might be. When people pee, that toilet water goes somewhere.

Drugs found in Puget Sound salmon from tainted wastewater

this post was submitted on 21 Jan 2025
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